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Analysis of saliva for drugs , Screening tests

المؤلف:  Sue Jickells , Adam Negrusz (Editors)

المصدر:  Clarkes Analytical Forensic Toxicology

الجزء والصفحة:  171

2026-10-07

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Analysis of saliva for drugs , Screening tests

Immunoassays to detect drugs in saliva must target or have significant cross-reactivity with the parent drug and lipophilic metabolites. For example, cocaine parent drug and ecgonine methyl ester, heroin and 6-MAM and D9-THC predominate in saliva because of their lipophilicity. When drugs are leached into saliva from buccal depots, as is the case for smoked drugs such as marijuana, smoked cocaine or heroin, parent drug and pyrolysis products predominate in the saliva. Immunoassays developed to detect the hydrophilic metabolites of drugs in urine are not appropriate for saliva screening. In addition, clinical trials and analysis of the sensitivity, specificity and predictive value of different putative cut-offs for saliva screening assays are required before the acceptance of specific immunoassays for saliva drug screening is widely adopted.