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Analysis of the main drugs of abuse

المؤلف:  Sue Jickells , Adam Negrusz (Editors)

المصدر:  Clarkes Analytical Forensic Toxicology

الجزء والصفحة:  p68-69

2026-09-19

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Analysis of the main drugs of abuse

It is not the intention of this section to give extensive details for the analysis of drugs of abuse. There are a plethora of methods available, with each laboratory adopting its own procedures depending on the aim of the analysis, the apparatus and/or equipment available, legal aspects, the number of analyses to be performed and possibly other details associated with the specific drugs’ seizure. Rather, an indication will be given of spot tests which can be used to indicate the presence or absence of a particular drug class, conditions which can be used if TLC analysis is required, an indication whether GC or HPLC is more appropriate and other factors that may need to be taken into consideration. Further details of analytical methods can be found in Moffat et al. (2004). Where GC analysis is applicable, separations for most drugs can be carried out on a capillary column with a dimethylpolysiloxane stationary phase (e.g. HP-1) (Moffat et al. 2004). The main variations between GC methods lie in the dimensions of the columns used and the temperature programme applied. For some drugs, derivatization is recommended. For HPLC, a wide variety of stationary mobile phase combinations are applied (Moffat et al. 2004), with both normal and reversed-phase systems in use). Information on TLC analysis for the various drugs is summarised in Table 3.4. Further details can be found in Moffat et al. (2004).