تسجيل الدخول

تسجيل

Collection of saliva , Sample treatment

المؤلف:  Sue Jickells , Adam Negrusz (Editors)

المصدر:  Clarkes Analytical Forensic Toxicology

الجزء والصفحة:  P170-171

2026-10-07

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Collection of saliva , Sample treatment

Cone (1993) stored collected saliva at 20C. The OraSure System (OraSure Technologies, Bethlehem, PA, USA) provides for shipping the oral fluid collected with the Intercept pad to a central laboratory for analysis after adding preservative fluid, with no special refrigeration. No sample treatment is required for immunoassay screening of saliva or dilutions of saliva. If the analyte of interest is unstable in aqueous solutions (e.g. cocaine) or subject to changes by oral fluid bacteria or enzymes (e.g. nitrazepam, flunitrazepam), further efforts at preservation may be required. Freezing the collected oral fluid reduces interference from mucins in pipetting and liquid–liquid extractions for chromatographic confirmation testing. Solid-phase extraction or solid-phase microextraction (SPME) reduces the need for freezing the sample (e.g. Hall et al. 1998; Lucas et al. 2000).