Movement of drugs into saliva , Excretion and diffusion
المؤلف:
Sue Jickells , Adam Negrusz (Editors)
المصدر:
Clarkes Analytical Forensic Toxicology
الجزء والصفحة:
167
2026-10-06
59
Movement of drugs into saliva
Excretion and diffusion
Some drugs, such as digoxin, steroids and hormones, are actively excreted into saliva by the acinar cells. Most drugs enter saliva by simple diffusion across the phospholipid bilayer of the acinar cells or through the cell membranes of the ductal cells in the tubules. Diffusion across cell membranes requires that the molecules be lipid-soluble, non-ionised and unbound. For this reason, the concentrations of drugs in saliva represent the free, non-ionised fraction in the blood plasma.
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