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تسجيل

Quality control and quality assurance , Limited specimen volume

المؤلف:  Sue Jickells , Adam Negrusz (Editors)

المصدر:  Clarkes Analytical Forensic Toxicology

الجزء والصفحة: 

2026-10-13

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Quality control and quality assurance

Limited specimen volume

For a variety of reasons, the volume of post mortem material available for analysis may be very limited. The problem faced by the toxicologist is how to make the best use of that material. With the widespread use of sensitive MS techniques, or even other GC and HPLC detection methods, it should seldom be necessary to base a single assay on more than 1 mL of specimen. However, even with an assay volume as low as or lower than 1 mL, the total amount of specimen may not permit the usual range of tests, or the normal level of sensitivity. Therefore, when such results are reported, it is important to reflect any such shortcomings in the final report, such as a higher LOD, or the inability to perform certain screening tests that otherwise might imply a false negative result.