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Date: 31-5-2021
2004
Date: 27-12-2015
2037
Date: 6-12-2015
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Heterosis
Heterosis is the phenomenon in which heterozygotes exhibit superiority of fitness over homozygotes . This superiority often occurs in the areas of viability, longevity, fecundity, and resistance to disease. Therefore, heterosis is sometimes referred to as “hybrid vigor”. Heterosis occurs when two different, often inbred strains are crossed. The effect of homozygous deleterious alleles is reduced in the heterozygotes produced through the cross. The increase in vigor may be due to overdominance or superiority of the heterozygote for particular gene differences, or to the introduction of favorable dominant alleles to loci previously homozygous for deleterious recessive alleles. Therefore, the terms “heterosis” and “overdominance” are used interchangeably; both confer heterozygotes with an evolutionary advantage over homozygotes.
When survival or reproduction is lowered with recessive alleles, such alleles are eliminated faster from inbred homozygous populations than from outbred, heterozygous populations. Homozygous deleterious alleles will first increase, and then natural selection will tend to remove the deleterious alleles, resulting in less genetic variation and greater average fitness as the heterozygous alleles increase. However, deleterious recessive genes will not be totally eliminated by selection, because they will not be exposed to selection in the heterozygotes.
The major histocompatibility complex (MHC) genes in humans and mouse are known to have extremely high numbers of alleles (Figure 1) (1). Since the number of alleles is much greater than expected if the alleles were all equivalent functionally, it has been long speculated that positive selection is operating on these complex genes. By making combinatorial sets of different alleles, an organism can become resistant to viral infection, which confers superiority of fitness over the homozygote. Thus, the MHC genes are counted as one example of overdominance.
Figure 1. The protein structure of the MHC human protein, HLA Class IA. The residues involved in binding antigen are shown by the closed circles (1).
Hughes and Nei (2) examined the numbers of synonymous and nonsynonymous substitutions in the MHC genes. They found that the number of nonsynonymous substitutions, which change the amino acid, was significantly greater than that of synonymous substitutions in the antigen-recognition sites, even though the opposite occurred elsewhere. They concluded that positive selection, most probably by overdominance or heterosis, is operating only on the antigen recognition sites.
References
1. T. Gojobori and T. Imanishi (1991) Transplantation Now 4, 26.
2. A. L. Hughes and M. Nei (1988) Nature 335, 167–170.
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دراسة يابانية لتقليل مخاطر أمراض المواليد منخفضي الوزن
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اكتشاف أكبر مرجان في العالم قبالة سواحل جزر سليمان
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اتحاد كليات الطب الملكية البريطانية يشيد بالمستوى العلمي لطلبة جامعة العميد وبيئتها التعليمية
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