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Date: 30-9-2018
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Date: 30-9-2018
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Date: 22-9-2018
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Catalysts within living things facilitate the vast and intricate system of chemical reactions required for life. There are two main types of naturally occurring catalytic biomolecules: ribozymes and enzymes.
Ribozymes are ribonucleic acid (RNA) molecules capable of catalyzing certain chemical reactions. Ribozymes are a relatively recent discovery, first reported in 1982, but their importance was demonstrated by the awarding of the 1989 Nobel Prize to the discoverers Sidney Altman and Thomas Cech. Research is ongoing to better understand these catalysts and develop new therapeutics and medicines using them.
Enzymes are protein molecules that catalyze biochemical reactions. They are remarkably specific for the reactants they can use, known as substrates, and many dramatically increase reaction rate by factors of 107 to 1014. A simple model often used to describe enzyme activity is known as the lock-and-key model (Figure 1.1 “Lock-and-Key Model of Enzymatic Catalysis”). In this model, enzymes accelerate reactions by providing a tight-fitting area, known as the active site, where substrate molecules can react. Hydrophobicity and intermolecular forces such as hydrogen bonding, London-dispersion forces, and dipole-dipole interactions facilitate the binding of substrate molecules to the active site, forming an enzyme-substrate complex. When the reaction is completed at the active site, the product is released.
Figure 1.1. Lock-and-Key Model of Enzymatic Catalysis
Lock-and-key model of enzymatic catalysis showing the tight-fitting area where substrate molecules react
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مخاطر خفية لمكون شائع في مشروبات الطاقة والمكملات الغذائية
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"آبل" تشغّل نظامها الجديد للذكاء الاصطناعي على أجهزتها
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تستخدم لأول مرة... مستشفى الإمام زين العابدين (ع) التابع للعتبة الحسينية يعتمد تقنيات حديثة في تثبيت الكسور المعقدة
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