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Effects of CNS Lesions

المؤلف:  Kim E. Barrett, Susan M. Barman, Heddwen L. Brooks, Jason X.-J. Yuan

المصدر:  Ganongs Review of Medical Physiology

الجزء والصفحة:  25th E, P172

2026-10-14

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Clinical Box 1 describes some of the deficits noted after damage within the somatosensory pathways. Clinical Box2 describes the characteristic changes in sensory and motor functions that occur in response to spinal hemisection.

CLINICAL BOX .1

CLINICAL BOX .2

Damage to the dorsal columns leads to ipsilateral loss of the ability to detect light touch, vibration, and proprioception from body structures represented caudal to the level of damage. Damage to the ventrolateral spinothalamic pathway leads to contralateral loss of pain and temperature sensation below the level of the lesion. Such spinal damage could occur with a penetrating wound or a tumor.

Lesions of the primary somatosensory cortex do not abolish somatic sensation. Irritation of this region causes paresthesia or an abnormal sensation of numbness and tingling on the contralateral side of the body. Destructive lesions impair the ability to localize noxious stimuli in time, space, and intensity. Damage to the cingulate cortex impairs the recognition of the aversive nature of a noxious stimulus.

An infarct in the thalamus can lead to a loss of sensation. Thalamic pain syndrome is sometimes seen during recovery from a thalamic infarct. The syndrome is characterized by chronic pain on the side of the body contralateral to the stroke.