تسجيل الدخول

تسجيل

Cell Types Used for CAR Generation: Neutrophils

المؤلف:  Armin Ghobadi & John F. DiPersio

المصدر:  Gene and Cellular Immunotherapy for Cancer

الجزء والصفحة:  p65-66

2026-09-02

17

Neutrophils, like macrophages, often have pro-tumor functions, however they are relatively less well characterized in the tumor microenvironment. Their ability to kill through alternative mechanisms, such as netosis, is conceptually appealing. Before CAR T-cells had gained significant momentum, a report in 1998 of neutrophils being modified with a CAR (then called a CIR, for chimeric immune receptor) containing a CD3z intracellular domain showed antigen-specific tumor lysis. However, no CAR neutrophil reports have been generated since. Whether these cells may someday play a more central role in CAR therapies remains to be seen (Fig. 1).

Fig1. Sources of CAR Engineered Immune Cells. The most common source of CAR-modified cells is autologous peripheral blood. However, allogeneic sources are being used and further developed, as are cord blood cells, induced pluripotent stem cell (iPSCs), or even cell lines in the case of CAR NK cells