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Biosynthesis of Triacylglycerols:- Plasmalogen Synthesis Requires Formation of an Ether-Linked Fatty Alcohol

المؤلف:  David L. Nelson، Michael M. Cox

المصدر:  Lehninger Principles of Biochemistry

الجزء والصفحة:  p813-814

2026-07-01

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Biosynthesis of Triacylglycerols:- Plasmalogen Synthesis Requires Formation of an Ether-Linked Fatty Alcohol

The biosynthetic pathway to ether lipids, including plasmalogens and the platelet-activating factor (see Fig. 10–9), involves the displacement of an esterified fatty acyl group by a long-chain alcohol to form the ether linkage (Fig. 21–30). Head-group attachment follows, by mechanisms essentially like those used in formation of the common ester-linked phospholipids. Finally, the characteristic double bond of plasmalogens (shaded blue in Fig. 21–30) is introduced by the action of a mixed-function oxidase similar to that responsible for desaturation of fatty acids (Fig. 21–13). The peroxisome is the primary site of plasmalogen synthesis.

FIGURE 21–30 Synthesis of ether lipids and plasmalogens. The newly formed ether linkage is shaded pink. The intermediate 1-alkyl-2-acyl glycerol 3-phosphate is the ether analog of phosphatidic acid. Mechanisms for attaching head groups to ether lipids are essentially the same as for their ester-linked analogs. The characteristic double bond of plasmalogens (shaded blue) is introduced in a final step by a mixed-function oxidase system similar to that shown in Figure 21–13.