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Specific Enzymes are Associated with Compartments Separated by the Mitochondrial Membranes

المؤلف:  Peter J. Kennelly, Kathleen M. Botham, Owen P. McGuinness, Victor W. Rodwell, P. Anthony Weil

المصدر:  Harpers Illustrated Biochemistry

الجزء والصفحة:  32nd edition.p122

2026-04-16

818

The mitochondrialmatrix(the internal compartment) is enclosed by a double membrane. The outer membrane is permeable to most metabolites and the inner membrane is selectively permeable (Figure 1). The outer membrane is characterized by the presence of various enzymes, includingacyl-CoA synthetase and glycerol phosphate acyltransferase. Other enzymes, including adenylyl kinase and creatine kinase are found in the intermembrane space. The phospholipid cardiolipin is concentrated in the inner membrane together with the enzymes of the respiratory chain, ATP synthase, and various membrane transporters.

Fig1. Structure of the mitochondrial membranes. Note that the inner membrane contains many folds or cristae.