Plasmacytoid Dendritic Cells
المؤلف:
Hoffman, R., Benz, E. J., Silberstein, L. E., Heslop, H., Weitz, J., & Salama, M. E.
المصدر:
Hematology : Basic Principles and Practice
الجزء والصفحة:
8th E , P208
2025-11-30
42
pDCs are distinguished by high levels of CD123, CD303 (BDCA 2), and CD304 (BDCA-4) and the lack of CD11c, AXL, Siglec-6 expression.11 Transcription factor Tcf4 specifically regulates the development of pDCs.21 pDCs can also be recognized by their distinct morphology resembling secretory plasma cells with a round shape and well-defined endoplasmic reticulum (ER).22,23 Although small fractions of pDCs may be found in blood, they primarily reside in lymphoid tissues. The hallmark of pDCs is the ability to produce large quantities of type I interferons, IFN-α/β, although they have been shown to produce type III interferon, IFN-λ, as well.24,25 pDCs produce interferons in response to recognition of viral RNA or DNA through TLR7 and TLR9, respectively, and exert potent antiviral effects. The activation of TLR7/9 may also lead to the production of tumor-necrosis factor-α (TNF-α) and IL-6 by pDCs, which contributes to pDC maturation, antibody production by B cells, and generation of tolerogenic T cells.
pDCs lack the capacity for antigen presentation and T cell stimulation in an immature state, suggesting they are less important for the activation of naïve T cells. However, recent studies have shown that upon activation, a subset of pDCs differentiates into a more cDC-like state by adopting a dendritic morphology, upregulating HLA-DR, CD80, and CD11c and downregulating TCF4. This activated pDC subpopulation has antigen-presenting capacity and can prime T cells, highlighting the high degree of DC heterogeneity and plasticity.
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