Hepatitis Type D (Delta Hepatitis)
المؤلف:
Stefan Riedel, Jeffery A. Hobden, Steve Miller, Stephen A. Morse, Timothy A. Mietzner, Barbara Detrick, Thomas G. Mitchell, Judy A. Sakanari, Peter Hotez, Rojelio Mejia
المصدر:
Jawetz, Melnick, & Adelberg’s Medical Microbiology
الجزء والصفحة:
28e , p516
2025-11-30
65
An antigen–antibody system termed the delta antigen (delta Ag) and antibody (anti-delta) is detected in some HBV infections. The antigen is found within certain HBsAg particles. In blood, HDV (delta agent) contains delta-Ag (HDAg) surrounded by an HBsAg envelope. It has a particle size of 35–37 nm and a buoyant density of 1.24–1.25 g/mL in CsCl. The genome of HDV consists of single-stranded, circular, negative-sense RNA, 1.7 kb in size. It is the smallest of known human pathogens and resembles subviral plant pathogens (ie, viroids). No homology exists with the HBV genome. HDAg is the only protein coded for by HDV RNA and is distinct from the antigenic determinants of HBV. HDV is a defective virus that requires the HBsAg coat for transmission. It is often associated with the most severe forms of hepatitis in HBsAg positive patients. It is classified in the Deltavirus genus, which is not assigned to any virus family.
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