HIV and AIDS are treated with modifi ed nucleosides Modified nucleosides
المؤلف:
Jonathan Clayden , Nick Greeves , Stuart Warren
المصدر:
ORGANIC CHEMISTRY
الجزء والصفحة:
1138
2025-08-12
482
HIV and AIDS are treated with modifi ed nucleosides Modified nucleosides
are among the best antiviral compounds. The anti-HIV drug AZT (zidovudine) is a slightly modified DNA nucleoside (3′-azidothymidine). It has an azide at C3′ instead of the hydroxyl group in the natural nucleoside. A more radically modifi ed nucleoside 3-TC (lami-vudine) is active against AZT-resistant viruses. This drug is based on cytosine with the sugar replaced by a different heterocycle, although it is recognizably similar, especially in the stereo chemistry. Acyclovir (Zovirax), the cold sore (herpes) treatment, is a modifi ed guanosine in which only a ghost of the sugar remains. There is no ring at all and no stereochemistry.
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