platelet volume, mean (Mean platelet volume [MPV])
المؤلف:
Kathleen Deska Pagana, Timothy J. Pagana, Theresa Noel Pagana.
المصدر:
Mosbys diagnostic and laboratory test reference
الجزء والصفحة:
15th edition , p709
2025-08-06
526
Type of test Blood
Normal findings 7.4-10.4 fL
Test explanation and related physiology
The MPV is a measure of the volume of a large number of platelets determined by an automated analyzer. MPV is to plate lets as mean corpuscular volume is to the RBC.
The MPV varies with total platelet production. In cases of thrombocytopenia, despite normal reactive bone marrow (e.g., hypersplenism), the normal bone marrow releases immature platelets to attempt to maintain a normal platelet count. These immature platelets are larger, and the MPV is elevated. When bone marrow production of platelets is inadequate, the platelets that are released are small. This is reflected as a low MPV; in this way, the MPV is useful in the differential diagnosis of thrombocytopenic disorders.
Procedure and patient care
• See inside front cover for Routine Blood Testing.
• Fasting: no
• Blood tube commonly used: lavender
• If the patient is known to have a low platelet count, perform the following steps:
1. Observe the patient for signs and symptoms of bleeding.
2. Check for blood in the urine and all excretions.
3. Assess the patient for bruises, petechiae, bleeding of the gums, epistaxis, and low back pain.
Abnormal findings
Increased levels
- Valvular heart disease
- Immune thrombocytopenia
- Massive hemorrhage
- B12 or folate deficiency
- Myelogenous leukemia
Decreased levels
- Aplastic anemia
- Chemotherapy-induced myelosuppression
- Wiskott–Aldrich syndrome
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