Type of test Blood

Normal findings Negative

Test explanation and related physiology

 The HLA antigens exist on the surface of white blood cells and on the surface of all nucleated cells in other tissues. The presence or absence of these antigens is determined genetically. Each gene controls the presence or absence of HLA A, B, C, or D.

The HLA system is used to assist in the diagnosis of certain diseases. For example, HLA-B27 is present in 80% of patients with Reiter syndrome. When a patient has recurrent and multiple arthritic complaints, the presence of HLA-B27 supports the diagnosis of Reiter syndrome. Other HLA–disease associations are mentioned in the abnormal findings section.

The HLA system of antigens has been used to indicate tis sue compatibility in transplantation. Because HLA antigens are genetically determined, they can also be used to resolve paternity investigations.

 Procedure and patient care

 • See inside front cover for Routine Blood Testing.

 • Fasting: no

• Blood tube commonly used: verify with laboratory

Abnormal findings

 Increased levels (HLA B27 antigens present)

- Ankylosing spondylitis

-Reiter syndrome

-Yersinia enterocolitica arthritis

-Anterior uveitis

- Graves disease

-Celiac disease or gluten enteropathy

-Chronic active hepatitis

-Multiple sclerosis

-Myasthenia gravis

- Dermatitis herpetiformis

- Psoriasis

-Juvenile diabetes

- Hemochromatosis

-Rheumatoid arthritis

مواضيع ذات صلة

human T-cell lymphotropic virus (HTLV) I/II antibody

human placental lactogen (hPL, Human chorionic somatomammotropin [HCS])

human papillomavirus (HPV test, HPV DNA testing, HPV Genotyping, HPV mRNA testing)

Nucleic Acid –Based Tests

human chorionic gonadotropin (hCG, Pregnancy tests, hCG beta subunit)

homocysteine (Hcy)

HIV serologic and virologic testing

HIV RNA quantification (HIV viral load)

Molecules involved in Lipoprotein metabolism

Lipoproteins

Retinol Binding Protein

Direct Visualization Of The Organism