Making the starting materials more reactive
المؤلف:
Jonathan Clayden , Nick Greeves , Stuart Warren
المصدر:
ORGANIC CHEMISTRY
الجزء والصفحة:
ص217
2025-05-12
336
A more reactive starting material would be an acyl chloride: how about reacting one of these with a Grignard reagent?This approach can work—for example this reaction is successful.
Often, better results are obtained by transmetallating (see Chapter 9) the Grignard reagent, or the organolithium, with copper salts. Organocopper reagents are too unreactive to add to the product ketones, but they react well with the acyl chloride. Consider this reaction, for example: the product was needed for a synthesis of the antibiotic septamycin.
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