Preparation of Wittig reagents
المؤلف:
University of Missouri System
المصدر:
Organic Chemistry ii
الجزء والصفحة:
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12-10-2020
1669
Preparation of Wittig reagents
Wittig reagents are usually prepared from a phosphonium salt, which is in turn prepared by the reaction of triphenylphosphine with an alkyl halide via an SN2 reaction. The alkylphosphonium salt is deprotonated with a strong base such as n-butyllithium:
[Ph3P+CH2R]X− + C4H9Li → Ph3P=CHR + LiX + C4H10
1) SN2 reaction
2) Deprotonation (for simplicity the butyllithium has been written as if it were ionic, which it is not):
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