Reaction of organometallics with epoxides
المؤلف:
University of Missouri System
المصدر:
Organic Chemistry ii
الجزء والصفحة:
.................
11-10-2020
1548
Reaction of organometallics with epoxides
Grignard and organolithium reagents will also react with epoxides, attacking the less hindered carbon .
Being a strong nucleophile, the organometallic attacks the epoxide from the less hindered end of the epoxide ring. Note that in the product, the new C-C bond is made to the carbon neighboring the alcohol carbon. (In contrast, when organometallics add to carbonyls, the new C-C bond ends up directly bonded to the alcohol carbon.)
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