Reaction of organometallic reagents with polar bonds
المؤلف:
University of Missouri System
المصدر:
Organic Chemistry ii
الجزء والصفحة:
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9-10-2020
2615
Reaction of organometallic reagents with polar bonds
Both ‘Grignard reagents’ and organolithiums are particularly useful in nucleophilic addition reactions with carbonyl electrophiles, such as ketones:
The nucleophilic carbon need not be primary as in the picture above. The synthesis of 2-phenyl-2-propanol, for example, can be carried by reacting phenylmagnesium bromide with acetone.
Addition to formaldehyde gives 1o alcohols
Addition to aldehydes gives 2o alcohols
Addition to ketones gives 3o alcohols
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