3:44:14 
2023-10-22 
416
An experimental gene therapy using a modified herpes virus has shown promise as a treatment for brain cancer, according to a new study.
A phase 1 study by scientists at Brigham and Women's Hospital in Boston, Massachusetts, found evidence that the herpes simplex virus can trigger a response in the body that will trigger a person's immune system to attack brain cancer cells.
The treatment, called CAN-3110, is modified to ensure that healthy cells are not killed as well
“Unlike other treatments to date, we were able to show that a single time-point administration of CAN-3110 is enough to activate the patient's immune cells traffic and fight the cancer, and we showed that this correlates with Survival responses.
In fact, brain cancers are difficult to treat, as traditional cancer treatments such as chemotherapy and radiation often cannot rid the body of all types of cancer. Glioblastoma (GBM), one of the most deadly types of cancer, is incurable, with an average of Survival time is about eight months.
In the laboratory, his team designed a tumor-selective biological agent based on the herpes virus. The idea was that this could be injected into glioblastoma patients to “reshape” the glioblastoma to make it less able to evade the patient’s immune cells.
The treatment contains a gene called ICP34.5, which helps the herpes virus cause illness in humans through cold sores or genital herpes.
Scientists believe that this gene is key to triggering a strong enough immune response to brain cancer cells.
In a phase 1 study published in Nature, the team gave 41 patients with recurrent glioblastoma a single dose of CAN-3110.
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