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Date: 13-9-2021
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Summary of The Reactions of Glycolysis and Gluconeogenesis
Of the 11 reactions required to convert pyruvate to free glucose, 7 are catalyzed by reversible glycolytic enzymes (Fig. 1). The 3 irreversible reactions (catalyzed by hexokinase/glucokinase, PFK-1, and PK) are circumvented by reactions catalyzed by glucose 6-phosphatase, fructose 1,6-bisphosphatase, PC, and PEPCK. In gluconeogenesis, the equilibria of the reversible glycolytic reactions are pushed toward glucose synthesis as a result of the essentially irreversible formation of PEP, fructose 6-phosphate, and glucose by the gluconeogenic enzymes. [Note: The stoichiometry of gluconeogenesis from two pyruvate molecules couples the cleavage of six high-energy phosphate bonds and the oxidation of two NADH with the formation of one glucose molecule (see Fig. 1).]
Figure 1: Summary of the reactions of glycolysis and gluconeogenesis, showing the energy requirements of gluconeogenesis. The numbered reactions are unique to gluconeogenesis. P = phosphate; GDP and GTP = guanosine diand triphosphates; NAD(H) = nicotinamide adenine dinucleotide; ADP = adenosine diphosphate.
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دراسة يابانية لتقليل مخاطر أمراض المواليد منخفضي الوزن
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اكتشاف أكبر مرجان في العالم قبالة سواحل جزر سليمان
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المجمع العلمي ينظّم ندوة حوارية حول مفهوم العولمة الرقمية في بابل
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