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Date: 5-8-2018
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Date: 12-7-2016
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Date: 3-12-2015
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Earlier, we examined the aldol reactions as a nucleophilic carbonyl addition in section 20.6, in which the electrophile is the carbonyl carbon of an aldehyde or ketone. A nucleophilic enolate can also attack the carbonyl carbon of a carboxylic acid derivative in a nucleophilic acyl substitution reaction.
This is referred to as a Claisen condensation, after the German chemist Ludwig Claisen (1851-1930).
Basic reaction
Going from reactants to products simply
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